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To manipulate something means to handle or use it skillfully, which involves a degree of expertise and control. This term often implies an understanding of the object or situation being dealt with, allowing for effective and sometimes strategic adjustments or alterations. In various contexts, manipulation can refer to physical objects, data, or even social situations, where the skillful handling produces desired results.

In contrast, the other options do not encapsulate the essence of manipulation. Ignoring or dismissing indicates a lack of engagement rather than a skillful handling of something. Observing something carefully may involve attention but does not suggest any action or skillful use regarding that object or situation. Complicating unnecessarily implies adding complexity rather than demonstrating skilled handling. Thus, the choice that best aligns with the definition of manipulation is handling or using something skillfully.